Longitudinal Changes of PAI-1, MMP-2, and VEGF in Peritoneal Effluents and Their Associations with Peritoneal Small-Solute Transfer Rate in New Peritoneal Dialysis Patients

Table 4

Linear regression analysis for association between biomarkers, covariates, and 4-hour D/P creatinine measured at two-year follow-up.

Variables	Univariate		Multivariate
	Beta	P	Beta	P
VEGF(pg/ml)
Baseline	0.26	0.029	-0.09	0.604
6 months	0.14	0.248	-0.001	0.994
PAI-1(ng/ml)
Baseline	0.34	0.004	0.36	0.039
6 months	0.2	0.11	-0.28	0.103
MMP-2(ng/ml)
Baseline	0.32	0.006	-0.07	0.694
6 months	0.56	<0.001	0.69	<0.001
Covariates
Age (years)	-0.06	0.600	-0.13	0.257
Gender, Male (n, %)	0.06	0.613	-0.06	0.611
Diabetes mellitus (n, %)	0.07	0.564	0.01	0.902
ACEi/ARB (n, %)	0.19	0.107	0.17	0.113
Statin (n, %)	-0.12	0.337	-0.04	0.739
Hemoglobin(g/dL)	-0.03	0.788	0.04	0.719
Albumin(g/dL)	-0.24	0.047	0.02	0.888
Fasting glucose(mg/dl)	0.19	0.128	0.06	0.611

Multivariate model includes VEGF, PAI-1, and MMP2 measurements at two time points and adjusted for covariates including age, gender, DM, ACEi/ARB, statin, hemoglobin, albumin, and glucose.