Mitochondrial Division Inhibitor 1 Attenuates Mitophagy in a Rat Model of Acute Lung Injury
Figure 1
Mdivi-1 treatment attenuates lung histopathology and pulmonary function. (a) Comparison of the morphological changes of the lung tissues (200 × magnification). Hematoxylin and eosin staining: the LPS + vehicle group displayed severe inflammatory cell infiltration, diffuse edema with less alveolar space, and increased interstitial congestion. Moderate (3 mg/kg) and high (5mg/kg) doses of Mdivi-1 treatment markedly prevented the morphological changes induced by LPS administration. (b to d) Increased lung injury score and lung W/D ratio, as well as decreased PaO2/FiO2, were observed in the LPS + vehicle group, which were improved following both the moderate or high dose of Mdivi-1 treatment. Data are expressed as the mean ± SD (n = 6 in each group). P < 0.05 versus control group; #P < 0.05 versus LPS + vehicle group.