Mitochondrial Division Inhibitor 1 Attenuates Mitophagy in a Rat Model of Acute Lung Injury

Figure 2

Mdivi-1 treatment inhibits the mitophagy activation. Mdivi-1 treatment prevented the LPS-induced loss of mitochondrial mass without influencing mitochondrial biogenesis and overall autophagy. (a) representative images of western blot results are shown; (b to g) semiquantitative analysis of protein levels. The values are expressed as the mean ± SD (n = 6 in each group). P < 0.05 versus control group; #P < 0.05 versus LPS + vehicle group; &P >0.05 versus LPS + vehicle group. TIM23, translocase of inner mitochondrial membrane 23 homolog; PGC-1α: peroxisome proliferator-activated receptor gamma, coactivator 1 alpha; mt-TFA, mitochondrial transcription factor A.

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