Mitochondrial Division Inhibitor 1 Attenuates Mitophagy in a Rat Model of Acute Lung Injury

Figure 6

Mdivi-1 downregulated the levels of proinflammatory cytokines as well as the lung inflammatory cells recruitment. The levels of inflammatory mediators were elevated in the LPS + vehicle group, but decreased with Mdivi-1 treatment group. (a to c) TNF-α, IL-1β and IL-6 level in BALF. (d to f) TNF-α, IL-1β and IL-6 level in lung. (g) Lung MPO activity. (h) Evans Blue (EB) content in lungs. (i) Images of western blot result and semiquantitative analysis of F4/80 level. Data are presented as the mean ± SD (n = 6 in each group). P < 0.05 versus control group; #P < 0.05 versus LPS + vehicle.

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