Research Article

Intestinal Immunomodulation and Shifts on the Gut Microbiota of BALB/c Mice Promoted by Two Bifidobacterium and Lactobacillus Strains Isolated from Human Samples

Table 1

Percentage of variation (Δ) with respect to time 0 (considered as 100%) of the relative abundance of different intestinal microbial groups (Table S1) after eight days of daily administration to adult BALB/c mice of vehicle (PBS), B. animalis subsp. lactis IPLA 20020 (fresh or lyophilized), and fresh L. gasseri IPLA 20212. “Others” refers to the rest of microbial groups not determined in the present work. The nonparametric Kruskal-Wallis and pairwise comparison with Dunn’s test were used to compare the four groups of mice. Different letters in superscript indicate significant differences among groups of animals receiving different probiotics or placebo (p < 0.05).

Microbial groupsControlB. animalis subsp. lactis IPLA 20020B. animalis subsp. lactis IPLA 20020 lyophilizedL. gasseri IPLA 20212

Δ Bacteroides-Prevotella-Porphyromonas -0.59 ± 18.00-13.51 ± 17.19-14.47 ± 25.41-13.20 ± 12.80
Δ Bifidobacterium33.84 ± 58.3611.16 ± 38.2749.26 ± 96.9839.11 ± 63.89
Δ Lactobacillus-Weissella -57.31 ± 32.60183.35 ± 355.62271.12 ± 309.88353.10 ± 483.71
Δ Enterobacteriaceae262.40 ± 232.18169.54 ± 262.9863.63 ± 101.26-40.26 ± 31.67
Δ Clostridium cluster XIVa219.30 ± 320.62-18.02 ± 72.0533.07 ± 172.02-18.11 ± 23.91
Δ Others-10.54 ± 144.4524.83 ± 29.66171.26 ± 341.3330.65 ± 34.65