Alda-1 Prevents Pulmonary Epithelial Barrier Dysfunction following Severe Hemorrhagic Shock through Clearance of Reactive Aldehydes

Figure 3

Lung injury in (a) sham, (b) hemorrhagic shock + placebo, and (c) hemorrhagic shock + Alda-1-treated rats (magnification, × 400). Lung injury was defined as intra-alveolar congestion, intra-alveolar hemorrhage, intra-alveolar and interstitial infiltration of leukocyte infiltration and thickening of the alveolar wall/hyaline membrane. Lung injury scores of sham, hemorrhagic shock + placebo, and hemorrhagic shock + Alda-1 treated rats are presented in (d). P<0.05, hemorrhagic shock + placebo versus hemorrhagic shock + Alda-1; #P<0.05, hemorrhagic shock + placebo versus sham; $P<0.05, hemorrhagic shock + Alda-1 versus sham.

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