Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis
Figure 3
Quantitative real-time PCR results of eight common genes screened in all four datasets. (a) GK, (b) PFKFB3, (c) CEACAM1, (d) TNFAIP6, (e) PSTPIP2, (f) SOCS3, (g) IL18RAP, and (h) LILRA5 relative expression comparison between Staphylococcus aureus/ Escherichia coli samples and controls. Expression of 18S rRNA was used as internal standard for normalization. represents p < 0.01, represents p < 0.001, when comparing Staphylococcus aureus group with mock infected group; ### represents p < 0.001, when comparing Escherichia coli group with mock infected group (one-way ANOVA followed by the Tukey test). CEACAM1: carcinoembryonic antigen related cell adhesion molecule 1; GK: glycerol kinase; PFKFB3: 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3; TNFAIP6: TNF alpha induced protein 6; IL18RAP: interleukin 18 receptor accessory protein; LILRA5: leukocyte immunoglobulin like receptor A5; PSTPIP2: proline-serine-threonine phosphatase interacting protein 2; SOCS3: suppressor of cytokine signaling 3.