Research Article

Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis

Table 1

Summary of representative clinical studies comparing the host transcriptomic responses in Staphylococcus aureus-/Escherichia coli-induced sepsis.

Published articleDataset accession number;
 platform
Clinical settingCell typePatient groupControl groupMicrobiological causeInfection sourceSampling time

Wong HR, et al (2007, 2012) [7, 8]; Cvijanovich N, et al (2008) [9]GSE4607;
GPL570
PICUWhole bloodSeptic shock(n=42)Outpatients or inpatients without infective pathology(n=15)S. aureus(n=9);
E. coli(n=3)
Lung, blood, urinary tract, colitis, CNS, abdominal, soft tissue, unknown1-3 days
Smith CL, et al (2014) [10]; Dickinson P (2015) [11]GSE25504;
GPL6947
Neonatal unitWhole bloodSepsis(n=26)Inpatients without infective pathology(n=35)S. aureus(n=18); E. coli(n=1)Lung, CNS, urinary tract, abdominal, soft tissue, unspecifiedWithin 6 hours
Ahn SH, et al (2013) [12]GSE33341;
GPL571
Adult inpatientWhole bloodSepsis with positive blood cultures(n=51)Healthy volunteers(n=43)S. aureus(n=32); E. coli(n=19)Lung, urinary tract, endocarditis, skin, catheter, bone, CNS, unknown1day
Dix A, et al (2015) [13]GSE65088;
GPL10558
noneWhole bloodAnti-coagulated blood of healthy human donors was incubated with bacteria or fungi(n=36)Anti-coagulated blood of healthy human donors was incubated with mock-infected control(n=20)S. aureus(n=3);
E. coli(n=4)
blood8 hours

Note. PICU: pediatric intensive care unit; CNS: central nervous system.
GEO Datasets information from PubMed (https://www.ncbi.nlm.nih.gov/geo).