Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis

Table 2

Top 10 enriched gene ontology (GO) terms in (a) Staphylococcus aureus samples and (b) Escherichia coli samples.

(a) Staphylococcus aureus

GO Term (Biological Process)	Function description	Gene count	P-value	Gene symbol
GO.0006952	defense response	15	2.37E-04	ANXA3, CCR7, CD247, FAIM3, FCGR1B, FFAR2, HP, IL1RN, LCN2, PLSCR1, S100A12, SERPING1, SOCS3, TNFAIP6, TXN
GO.0006955	immune response	14	4.23E-04	ANXA3, CCR7, CD247, CD96, CST7, FCGR1B, FFAR2, IL7R, LCN2, LEF1, S100A12, SERPING1, SOCS3, TXN
GO.0002376	immune system process	16	7.81E-04	ANXA3, CCR7, CD247, CD96, CEACAM1, CST7, FAIM3; FCGR1B, FFAR2, HP, LCN2, PLSCR1, S100A12, SERPING1, SOCS3, TXN
GO.0050776	regulation of immune response	11	7.81E-04	CCR7, CD247, CD96, FCGR1B, FFAR2, IL7R, OLFM4, PLSCR1, SAMSN1, SERPING1, SOCS3
GO.0002682	regulation of immune system process	13	1.87E-03	CCR7, CD247, CD96, FCGR1B, FFAR2, IL7R, LEF1, OLFM4, PLSCR1, SAMSN1, SERPING1, SOCS3, STOM
GO.0048583	regulation of response to stimulus	19	4.55E-03	CCR7, CD247, CD96, FCGR1B, FFAR2, HP, IL18R1, IL1RN, IL7R, LEF1, MMP9, OLFM4, PLSCR1, S100A12, SAMSN1, SERPING1, STOM, TNFAIP6, TXN
GO.0065009	regulation of molecular function	17	4.68E-03	ACSL1, ANXA3, CCR7, CST7, HP, ID3, IL1RN, LEF1, MMP9, PLSCR1, S100A12, SERPINB1, SERPING1, SOCS3, SORT1, STOM, TXN
GO.0044092	negative regulation of molecular function	11	6.64E-03	ANXA3, CST7, HP, ID3, IL1RN, LEF1, MMP9, SERPINB1, SERPING1, SOCS3, SORT1
GO.0050790	regulation of catalytic activity	15	8.01E-03	ACSL1, ANXA3, CCR7, CST7, HP, IL1RN, LEF1, MMP9,; PLSCR1, S100A12, SERPINB1, SERPING1, SOCS3, SORT1, TXN
GO.0071345	cellular response to cytokine stimulus	8	8.51E-03	ACSL1, CCR7, FCGR1B, IL18R1, IL1RN, IL7R, LEF1, SOCS3

(b) Escherichia coli

GO Term; (Biological Process)	Function description	Gene count	P-value	Gene symbol
GO.2001267	regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	5	2.61E-04	JAK2, MMP9, TNFRSF10A, TNFRSF10B, TNFSF10
GO.0010951	negative regulation of endopeptidase activity	8	1.20E-03	LEF1, MMP9, SERPINB1, SERPING1, TIMP1, TNFRSF10A, TNFRSF10B, TNFSF10
GO.0097296	activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway	4	1.20E-03	JAK2, TNFRSF10A, TNFRSF10B, TNFSF10
GO.0052548	regulation of endopeptidase activity	9	1.82E-03	JAK2, LEF1, MMP9, SERPINB1, SERPING1, TIMP1, TNFRSF10A, TNFRSF10B, TNFSF10
GO.0051346	negative regulation of hydrolase activity	9	2.24E-03	LEF1, MMP9, SERPINB1, SERPING1, SORT1, TIMP1, TNFRSF10A, TNFRSF10B, TNFSF10
GO.0043086	negative regulation of catalytic activity	12	2.44E-03	ANXA3, HP, LEF1, MMP9, SERPINB1, SERPING1, SOCS3, SORT1, TIMP1, TNFRSF10A, TNFRSF10B, TNFSF10
GO.0050790	regulation of catalytic activity	19	2.52E-03	ANXA3, CCR7, FPR1, HP, JAK2, LEF1, MMP9, PFKFB2, PLSCR1, RASGRP1, SERPINB1, SERPING1, SOCS3, SORT1, TIMP1, TNFRSF10A, TNFRSF10B, TNFSF10, VPS9D1
GO.0006954	inflammatory response	9	2.59E-03	CCR7, FFAR2, HP, IL18RAP, ORM1, PLSCR1, RASGRP1, TLR5, TNFAIP6
GO.0009605	response to external stimulus	17	4.17E-03	ABLIM1, ANXA3, ARG1, AUTS2, BCL11B, CCR7, FFAR2, FPR1, HP, JAK2, LEF1, MMP9, PLSCR1, SOCS3, TNFRSF10A, TNFRSF10B, UPP1
GO.0044092	negative regulation of molecular function	13	4.17E-03	ANXA3, HP, JAK2, LEF1, MMP9, SERPINB1, SERPING1, SOCS3, SORT1, TIMP1, TNFRSF10A, TNFRSF10B, TNFSF10