BioMed Research International

Research Article

Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis

Table 4

Statistics (FC, T-test, and FDR-adjusted p-values) for the differently expressed genes in all four candidate datasets.

(a) Staphylococcus aureus

Gene symbol

GSE4607

GSE25504

GSE33341

GSE65088

P-value

T-Test

FDR

T-Test

FDR

T-Test

FDR

T-Test

FDR

CEACAM1

2.44

3.62E-07

3.54E-05

2.42

3.00E-10

1.03E-08

2.72

2.11E-21

9.92E-20

2.36

9.14E-05

9.33E-03

1.64

2.11E-09

9.94E-07

1.61

2.51E-10

9.01E-09

1.77

1.11E-18

2.81E-17

3.11

8.00E-07

7.88E-03

PFKFB3

2.54

7.83E-09

2.49E-06

1.87

5.36E-12

4.25E-10

2.13

5.85E-21

2.43E-19

1.89

7.01E-05

8.15E-03

TNFAIP6

1.77

1.43E-04

2.94E-03

2.53

7.09E-11

3.25E-09

3.18

3.06E-20

1.07E-18

1.97

9.19E-04

3.55E-02

(b) Escherichia coli

Gene symbol

GSE4607

GSE25504

GSE33341

GSE65088

P-value

T-Test

FDR

T-Test

FDR

T-Test

FDR

T-Test

FDR

CEACAM1

2.83

2.61E-07

1.44E-04

2.79

2.67E-03

3.90E-02

2.77

2.33E-18

1.01E-16

1.63

3.54E-05

3.57E-03

IL18RAP

2.42

2.40E-05

2.48E-03

2.65

8.07E-04

1.72E-02

2.27

3.74E-19

2.01E-17

2.06

8.72E-04

2.77E-02

LILRA5

2.27

1.16E-03

3.08E-02

2.32

2.02E-04

6.20E-03

2.84

7.28E-16

1.64E-14

2.58

3.50E-07

2.21E-04

PFKFB3

2.23

8.13E-06

1.32E-03

3.28

5.94E-11

2.34E-08

1.93

1.31E-16

3.57E-15

2.61

4.82E-06

1.03E-03

PSTPIP2

2.77

1.03E-08

1.82E-05

1.92

2.11E-07

2.37E-05

2.34

2.17E-24

7.80E-22

1.93

1.23E-03

3.46E-02

SOCS3

2.43

1.07E-04

6.73E-03

1.99

1.93E-14

2.29E-11

1.79

1.76E-13

2.38E-12

3.64

3.05E-07

2.10E-04

Note. FC: fold-change; FDR: false discovery rate; CEACAM1: carcinoembryonic antigen related cell adhesion molecule 1; GK: glycerol kinase; PFKFB3: 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3; TNFAIP6: TNF alpha induced protein 6; IL18RAP: interleukin 18 receptor accessory protein; LILRA5: leukocyte immunoglobulin like receptor A5; PSTPIP2: proline-serine-threonine phosphatase interacting protein 2; SOCS3: suppressor of cytokine signaling 3.