Research Article
Identification of Potential Transcriptional Biomarkers Differently Expressed in Both S. aureus- and E. coli-Induced Sepsis via Integrated Analysis
Table 4
Statistics (FC, T-test, and FDR-adjusted p-values) for the differently expressed genes in all four candidate datasets.
(a) Staphylococcus aureus |
| Gene symbol | GSE4607 | GSE25504 | GSE33341 | GSE65088 | | FC | P-value | FC | P-value | FC | P-value | FC | P-value | | | T-Test | FDR | | T-Test | FDR | | T-Test | FDR | | T-Test | FDR |
| CEACAM1 | 2.44 | 3.62E-07 | 3.54E-05 | 2.42 | 3.00E-10 | 1.03E-08 | 2.72 | 2.11E-21 | 9.92E-20 | 2.36 | 9.14E-05 | 9.33E-03 | GK | 1.64 | 2.11E-09 | 9.94E-07 | 1.61 | 2.51E-10 | 9.01E-09 | 1.77 | 1.11E-18 | 2.81E-17 | 3.11 | 8.00E-07 | 7.88E-03 | PFKFB3 | 2.54 | 7.83E-09 | 2.49E-06 | 1.87 | 5.36E-12 | 4.25E-10 | 2.13 | 5.85E-21 | 2.43E-19 | 1.89 | 7.01E-05 | 8.15E-03 | TNFAIP6 | 1.77 | 1.43E-04 | 2.94E-03 | 2.53 | 7.09E-11 | 3.25E-09 | 3.18 | 3.06E-20 | 1.07E-18 | 1.97 | 9.19E-04 | 3.55E-02 |
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(b) Escherichia coli |
| Gene symbol | GSE4607 | GSE25504 | GSE33341 | GSE65088 | | FC | P-value | FC | P-value | FC | P-value | FC | P-value | | | T-Test | FDR | | T-Test | FDR | | T-Test | FDR | | T-Test | FDR |
| CEACAM1 | 2.83 | 2.61E-07 | 1.44E-04 | 2.79 | 2.67E-03 | 3.90E-02 | 2.77 | 2.33E-18 | 1.01E-16 | 1.63 | 3.54E-05 | 3.57E-03 | IL18RAP | 2.42 | 2.40E-05 | 2.48E-03 | 2.65 | 8.07E-04 | 1.72E-02 | 2.27 | 3.74E-19 | 2.01E-17 | 2.06 | 8.72E-04 | 2.77E-02 | LILRA5 | 2.27 | 1.16E-03 | 3.08E-02 | 2.32 | 2.02E-04 | 6.20E-03 | 2.84 | 7.28E-16 | 1.64E-14 | 2.58 | 3.50E-07 | 2.21E-04 | PFKFB3 | 2.23 | 8.13E-06 | 1.32E-03 | 3.28 | 5.94E-11 | 2.34E-08 | 1.93 | 1.31E-16 | 3.57E-15 | 2.61 | 4.82E-06 | 1.03E-03 | PSTPIP2 | 2.77 | 1.03E-08 | 1.82E-05 | 1.92 | 2.11E-07 | 2.37E-05 | 2.34 | 2.17E-24 | 7.80E-22 | 1.93 | 1.23E-03 | 3.46E-02 | SOCS3 | 2.43 | 1.07E-04 | 6.73E-03 | 1.99 | 1.93E-14 | 2.29E-11 | 1.79 | 1.76E-13 | 2.38E-12 | 3.64 | 3.05E-07 | 2.10E-04 |
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Note. FC: fold-change; FDR: false discovery rate; CEACAM1: carcinoembryonic antigen related cell adhesion molecule 1; GK: glycerol kinase; PFKFB3: 6-phosphofructo-2-kinase/fructose-2, 6-biphosphatase 3; TNFAIP6: TNF alpha induced protein 6; IL18RAP: interleukin 18 receptor accessory protein; LILRA5: leukocyte immunoglobulin like receptor A5; PSTPIP2: proline-serine-threonine phosphatase interacting protein 2; SOCS3: suppressor of cytokine signaling 3.
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