The Effects of Oral Isotretinoin in Women with Acne and Polycystic Ovary Syndrome

Table 2

Comparisons of pre- and post-treatment hormone and biochemical parameters.

	Pre-treatment n=40	Post-treatment n=40	P-value
FSH	7,005(6,0825-8,24)	7(6,195-8,265)	0,906
LH	5,07(3,645-7,89)	6,09(4,38-8,64)	0,243
E2	43,5(34,25-64,25)	42(33,5-53,75)	0,416
Free-Testosterone	1,79(1,35-2,35)	1,51(1,21-2,01)	0,024
Total-Testosterone	0,435(0,332-0,575)	0,455(0,302-0,57)	0,965
SHBG	39(32,25-44)	37,5(32,5-50,75)	0,482
DHEASO4	197,65(160,67-274,55)	234,6(212,07-271,17)	0,104
IGF1	318,9±68,51	313,25±85,52	0,737
Insulin	10,19(6,29-12,17)	7,70(6,52-10,01)	0,062
Hemoglobin	12,77±0,99	12,50±0,82	0,009
PLT	306,6±60,23	310,9±62,47	0,499
AST	23(19-28)	24(20-28)	0,275
ALT	22(19-26)	25(21-26,75)	0,257
Triglyceride	121,5(103,5-132)	135(119,25-172)	<0,001
Cholesterol	133,23±20,39	153,32±27,32	<0,001
HDL	38,05±6,04	37,48±5,72	0,475

To test the normality assumption of the data, Shapiro Wilk was used. Values are expressed as mean ± standard deviation or median (25th percentile – 75 percentile). Parametric comparisons were made with t-test for two dependent groups; non-parametric comparisons were made with Wilcoxon Signed Ranks test. PASW Statistics 18 program was used for all comparisons. p<0.05 probability value was considered as statistically significant.