D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity

<div>(a) Docking of compound <b>8a</b>, the unsubstituted tetrahydrobenzo[6,7]indolizino[1,2-b]quinoline framework, onto the topoisomerase I–DNA complex. (b) Overlay of the docking poses of luotonin A and compound <b>8a</b>. (c) Docking of the 2-methyl derivative (compound <b>8e</b>). (d) Docking of the 2-chloro derivative (compound <b>8h</b>).</div>

BioMed Research International

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Figure 4

Figure 4: D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity 

Figure 4 | D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity 