D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity

<div>Topoisomerase II inhibition assays showing the effect of <b>8f</b> and <b>8h</b> (at IC<sub>50</sub> concentrations) on the decatenation of kDNA by 2U of human topoisomerase II.</div>

BioMed Research International

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Figure 7

Figure 7: D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity 

Figure 7 | D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity 