D-Ring-Modified Analogues of Luotonin A with Reduced Planarity: Design, Synthesis, and Evaluation of Their Topoisomerase Inhibition-Associated Cytotoxicity

Table 1

Calculated IC₅₀ values for the compounds tested (8a–i) towards MCF7, HCT116, JURKAT, and NCI-H460 cells for a 48 h period. Standard errors are given within parentheses.

Compounds	IC50 (μM; 48 h)
	MCF7	HCT116	JURKAT	NCI-H460
8a	213.56 (±3.45)	128.36 (±4.07)	148.54 (±2.75)	186.43 (±3.15)
8b	337.86 (±4.70)	132.34 (±2.04)	261.89 (±3.45)	280.51 (±2.25)
8c	335.65 (±2.25)	134.43 (±3.94)	146.78 (±3.15)	172.78 (±1.95)
8d	304.12 (±3.25)	144.16 (±3.45)	147.23 (±2.25)	221.89 (±3.85)
8e	324.54 (±3.80)	133.12 (±3.95)	158.45 (±2.40)	219.63 (±2.45)
8f	98.54 (±2.65)	68.60 (±3.35)	76.46 (±2.45)	84.47 (±2.15)
8g	146.54 (±3.75)	129.87 (±2.45)	176.99 (±3.25)	188.65 (±3.45)
8h	87.65 (±2.55)	57.35 (±2.45)	69.12 (±2.07)	76.36 (±2.65)
8i	140.73 (±3.07)	148.56 (±3.00)	128.45 (±2.15)	176.54 (±1.27)
CPT	41.59 (±3.85)	40.27 (±3.05)	41.48 (±3.15)	42.61 (±2.45)