The Nutritional Cytokine Leptin Promotes NSCLC by Activating the PI3K/AKT and MAPK/ERK Pathways in NSCLC Cells in a Paracrine Manner

Figure 3

The proliferation of NSCLC cells was inhibited by the downregulation of leptin in CAFs. (a) The efficiency of gene intervention by four different shRNA fragments was verified by western blot. (b) The proliferation of NSCLC cell lines treated with the CM of different fibroblasts was assessed with a colony formation assay. The quantification of cell colonies is shown in the bar chart.

(a)

(b)