The Effects of Once-Weekly Dulaglutide and Insulin Glargine on Glucose Fluctuation in Poorly Oral-Antidiabetic Controlled Patients with Type 2 Diabetes Mellitus
Table 3
CGMS results.
Dulaglutide group ()
Glargine ()
PT2.8
Baseline
0 (0, 0)
0 (0, 0)
0
1
52w
0 (0, 0)
0 (0, 0.50)
−1.925
0.054
AUC2.8
Baseline
0 (0, 0)
0 (0, 0)
0
1
52w
0 (0, 0)
0 (0, 0)
−1.333
0.182
PT3.9
Baseline
0 (0, 0)
0 (0, 0)
−0.15
0.88
52w
0 (0, 0)
0 (0, 8.00)
−0.446
0.656
AUC3.9
Baseline
0 (0, 0)
0 (0, 0)
0
1
52w
0 (0, 0)
0 (0, 0.05)
−1.925
0.054
PT3.9–7.8
Baseline
6.00 (0, 28.50)
10.00 (1.00, 33.00)
−0.605
0.545
52w
51.50 (27.00, 62.75)
44.00 (22.50, 66.50)
−0.482
0.63
PT3.9–10
Baseline
35.50 (4.25, 49.75)
36.00 (15.50, 53.50)
−0.34
0.734
52w
80.50 (66.00, 91.75)
56.00 (38.50, 86.50)
−1.359
0.174
PT10
Baseline
64.50 (49.50, 95.75)
64.00 (46.50, 84.50)
−0.34
0.734
52w
19.50 (8.00, 34.00)
25.00 (11.50, 54.50)
−1.048
0.295
AUC10
Baseline
2.05 (1.23, 4.50)
1.80 (1.05, 2.75)
−0.425
0.671
52w
0.30 (0.10, 1.28)
0.40 (0.10, 2.45)
−0.913
0.361
PT13.9
Baseline
25.00 (6.00, 41.25)
18.00 (8.00, 36.50)
−0.425
0.671
52w
0.50 (0, 11.50)
0 (0, 29.50)
−0.427
0.669
AUC13.9
Baseline
0.30 (0.03, 1.58)
0.30 (0.15, 0.45)
−0.23
0.818
52w
0 (0, 0.18)
0 (0, 0.65)
−0.513
0.608
MBG
Baseline
11.93 ± 3.00
11.26 ± 2.08
0.598
0.556
52w
8.63 ± 1.52
8.83 ± 2.00
−0.285
0.778
SDBG
Baseline
2.75 ± 0.65
2.67 ± 0.60
0.317
0.754
52w
2.24 ± 0.95
2.91 ± 1.31
−1.486
0.151
MAX
Baseline
17.70 ± 2.92
17.18 ± 2.31
0.46
0.65
52w
14.43 ± 3.47
15.14 ± 3.90
-0.472
0.641
MIN
Baseline
7.19 ± 2.70
6.43 ± 2.46
0.697
0.493
52w
5.06 ± 1.21
4.46 ± 1.62
1.065
0.298
Change
−2.30 (−3.08, −0.15)
−2.60 (−4.15, 1.25)
−0.17
0.865
LAGE
Baseline
10.52 ± 1.85
10.74 ± 1.85
−0.29
0.775
52w
8.98 ± 3.76
10.69 ± 3.86
−1.078
0.292
MAGE
Baseline
6.74 ± 1.99
6.88 ± 2.20
−0.157
0.877
52w
5.86 ± 2.81
7.09 ± 3.21
−0.997
0.329
-Value
Baseline
26.76 (16.31, 58.85)
24.80 (16.04, 34.97)
−0.481
0.63
52w
5.19 (2.47, 14.96)
10.75 (4.42, 33.65)
−1.585
0.113
MODD
Baseline
2.33 ± 1.33
2.33 ± 0.83
0.002
0.999
52w
1.91 ± 0.90
2.19 ± 0.62
−0.82
0.424
PT: Percentage time of blood glucose; AUC: area under the curve; MBG, mean blood glucose; SDBG: standard deviation of blood glucose; MAX: the maximum blood glucose; MIN: the minimum blood glucose; LAGE: the largest amplitude of glycemic excursion; MAGE: mean amplitude of glycemic excursion; MODD: absolute means of daily difference.
