Whole Genome Analysis and Prognostic Model Construction Based on Alternative Splicing Events in Endometrial Cancer

Table 2

Univariate and multivariate Cox regression analysis of clinicopathological parameters and risk score (All) in 523 EC patients.

Variables	Group	Patient; N=523	Univariate analysis		Multivariate analysis
			HR (95% CI)	P value	HR (95% CI)	P value
Age		521	1.607(0.83-3.112)	0.16
	<55	94
	≥55	427
BMI		492	0.995 (0.576-1.718)	0.986
	<25	91
	≥25	401
Subtype		523	2.993(1.96-4.57)	3.85E-07 ∗∗∗	1.332(0.626-2.835)	0.456
	Endometrioid	393
	Non-Endometrioid	130
Stage		523	4.123(2.691-6.316)	7.55E-11 ∗∗∗	2.832(1.362-5.888)	0.005∗∗
	I-II	378
	III-IV	145
Grade		523	11.692(2.876-47.53)	5.90E-04 ∗∗∗	1.32 (0.533-3.274)	0.549
	Low grade (G1)	96
	High grade (G2/G3)	427
Cancer status		495	9.018(5.817-13.98)	<2E-16 ∗∗∗	2.282(1.094-4.763)	0.028 ∗
	Tumor free	417
	With tumor	78
New tumor event after initial treatment		467	5.735 (3.54-9.292)	1.31E-12; ∗∗∗	1.738(0.9-3.359 )	0.1
	NO	387
	YES	80
Primary therapy outcome success		417	9.312(4.936-17.56)	5.54E-12 ∗∗∗	4.15 (1.741- 9.892)	1.33E-03 ∗∗
	CRR+SD+PRR	401
	PD	16
Radiation		505	0.64(0.404-1.016)	0.0586
	NO	278
	YES	227
Risk score (All)		499	5.823 (3.308-10.25)	1.02E-09 ∗∗∗	3.548(1.6-8.02)	2.05E-03 ∗∗
	Low	250
	high	249

Abbreviations: BMI, Body Mass Index; CRR, Complete Remission/Response; SD, Stable Disease; PRR, Partial Remission/Response; PD, Progressive Disease.