Lovastatin Enhances Cytotoxicity of Temozolomide via Impairing Autophagic Flux in Glioblastoma Cells
Lovastatin increased TMZ-induced cellular apoptosis in GBM cells. (a) U87 and U251 cells were treated with TMZ (500 μM), lovastatin (5 μM), or combination for 72 hrs; the cellular apoptotic level was detected by Annexin V/PI staining. (b) Quantification of flow cytometry-measured cell apoptotic levels; N = 3. (c) Apoptotic markers were detected by the western blot assay. GAPDH was used as an internal loading control. (d) Quantification of western blot results of apoptotic markers; N = 3. ;;;; ns = no significance.
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