Identification and Interaction Analysis of Significant Genes and MicroRNAs in Pterygium
Figure 2
Differentially expressed genes obtained from GES2513. (a) Volcano plot. There were 232 upregulated genes and 69 downregulated genes up to the standard and among these differentially expressed genes, about 36% downregulated genes involved in apoptosis, such as ATF3, NR4A2, NR4A1, EGR1, and JUN (in the top 10 downregulated genes), and over half of upregulated genes were related to extracellular matrix (ECM), including collagen family (COL1A2, COL3A1, COL4A1, COL4A2, COL6A1, COL6A3, and COL15A1) and matrix metalloproteinases family (MMP2 and MMP7). (b) Heat map of top 50 downregulated genes and top 50 upregulated genes. The 4 GEO samples (GSM) in the left columns were collected from normal conjunctiva tissues of cataract patients, while the 8 GSMs in the right columns were taken from lesional tissues of patients with pterygium.