Mesenchymal Stem Cells and Cancer: Clinical Challenges and Opportunities

Table 3

Effects of MSCs-derived exosomes on tumors.

Author	Exosome origin	Tumor model	Outcomes	Mechanisms
Li, Hongdan et al. [34]	Human bone marrow MSCs from patients undergoing hip-replacement surgery	Colon cancer cells (HCT-116, HT-29, and SW-480)	Increased the population of colon cancer stem cells	miR-142-3p in exosomes promoted the Notch signaling pathways by downregulating Numb
Zhang, Yanling et al. [35]	Human omental adipose-derived MSCs from cancer-free female donors	Human EOC cell lines (SKOV3, A2780, and HO-8910)	Promoted cancer progression	Affect proteomic profile of tumor cells via paracrine mechanism
Roccaro AM et al. [36]	Human bone marrow MSCs from normal or cancer patients	Multiple myeloma (MM) cells	MM BM-MSCs–derived exosomes promoted MM tumor growth, normal BM-MSC exosomes inhibited the growth of MM cells	Impact MM cell adhesion
Makiko Ono et al. [37]	Human bone marrow MSCs	BM2 cells	Slowed tumor growth	Exosomal; transfer of miR-23b and its suppression of MARCKS
Reza AM et al. [38]	Human adipose MSCs	A2780 and SKOV-3 ovarian cancer cells	Inhibited proliferation of ovarian cancer cells	Upregulates proapoptotic molecules