Table 3: Effects of MSCs-derived exosomes on tumors.

AuthorExosome originTumor modelOutcomesMechanisms

Li, Hongdan et al. [34]Human bone marrow MSCs from patients undergoing hip-replacement surgeryColon cancer cells (HCT-116, HT-29, and SW-480)Increased the population of colon cancer stem cellsmiR-142-3p in exosomes promoted the Notch signaling pathways by downregulating Numb

Zhang, Yanling et al. [35]Human omental adipose-derived MSCs from cancer-free female donorsHuman EOC cell lines (SKOV3, A2780, and HO-8910)Promoted cancer progressionAffect proteomic profile of tumor cells via paracrine mechanism

Roccaro AM et al. [36]Human bone marrow MSCs from normal or cancer patientsMultiple myeloma (MM) cellsMM BM-MSCs–derived exosomes promoted MM tumor growth, normal BM-MSC exosomes inhibited the growth of MM cellsImpact MM cell adhesion

Makiko Ono et al. [37]Human bone marrow MSCsBM2 cellsSlowed tumor growthExosomal
transfer of miR-23b and its suppression of MARCKS

Reza AM et al. [38]Human adipose MSCsA2780 and SKOV-3 ovarian cancer cellsInhibited proliferation of ovarian cancer cellsUpregulates proapoptotic molecules