Comparative Genomic Analysis of Trichinella spiralis Reveals Potential Mechanisms of Adaptive Evolution

Table 1

Gene functions for some of the positively selected genes identified in T. spiralis.

Gene function	GenBank No.	Gene family
Xenobiotic metabolism	EFV51745	oxidoreductase, short chain dehydrogenase/reductase family
	EFV54917	dimethylaniline monooxygenase [N-oxide-forming] 4
	EFV50316	cytochrome P450 4V2
	EFV50200	heparan sulfate glucosamine 3-O-sulfotransferase 3A1
	EFV57943	protein-tyrosine sulfotransferase A
	EFV50642	putative ABC transporter, ATP-binding protein
	EFV53848	putative ABC transporter, ATP-binding protein
	EFV54367	putative ABC transporter, ATP-binding protein
	EFV56075	putative ABC transporter, ATP-binding protein
	EFV48926	putative ABC transporter, ATP-binding protein, partial
DNA repair proteins	EFV4940	DNA mismatch repair protein Msh6
	EFV57314	DNA repair protein RAD51
	EFV55613	DNA repair protein Rad4
	EFV55989	DNA cross-link repair 1A protein
	EFV62248	DNA excision repair protein haywire
Penetration/digestion	EFV60084	lysosomal aspartic protease
	EFV52155	ATP-dependent Clp protease, proteolytic subunit ClpP
	EFV51535	putative ATP-dependent Clp protease, ATP-binding subunit ClpX
	EFV53966	cysteine protease ATG4B
	EFV54564	putative ATP-dependent protease La
Muscle cell transformation	EFV53122	putative helix-loop-helix DNA-binding domain protein
	EFV57695	putative helix-loop-helix DNA-binding domain protein
	EFV61981	putative helix-loop-helix DNA-binding domain protein
	EFV55197	cell differentiation protein RCD1-like protein
Cell cycle arrest	EFV56859	G2/mitotic-specific cyclin-B3
	EFV56912	cyclin-dependent kinase inhibitor 2B-related protein
Antiapoptotic and immunomodulatory activities	EFV60199	translationally-controlled tumor protein-like protein
Surface proteins used for creating new parasite-specific morphological structures
Cadherin	EFV54837	putative cadherin domain protein, partial
	EFV54875	putative cadherin domain protein, partial
	EFV57941	putative cadherin domain protein
Cuticle collagen	EFV60533	cuticle collagen 34 protein
	EFV60602	cuticle collagen 3
	EFV52694	cuticle collagen rol-6
	EFV52706	cuticle collagen dpy-7
	EFV52845	cuticle collagen dpy-13
Metabolic Pathways
β-oxidation pathway	EFV50357	putative 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain protein
	EFV58588	lonCoA ligase 5
Glycolysis	EFV55075	putative hexokinase HKDC1
	EFV52822	enolase
	EFV54356	L-lactate dehydrogenase
Phospholipid metabolism	EFV56439	phospholipase, patatin family
	EFV60905	phospholipase D3 protein
Epigenetic process regulatory machinery	EFV58204	putative CXXC zinc finger domain protein