Association between Retinal Nerve Fiber Layer Thickness and Eye Fatigue

Figure 4

Schematic presentation of our proposed classification process for eye fatigue. We hypothesize that eye fatigue originates from both visual and nonvisual etiologies, with corneal hyperesthesia and photosensitivity playing major roles in nonvisual eye fatigue. Recent findings of neuropathic pain and ipRGCs underlie this classification model, whereby corneal pain might be mediated by ipRGCs, although the detailed neural mechanisms of dryness and photosensitivity remain elusive. ipRGCs, intrinsically photosensitive retinal ganglion cells.