Table 4: Function roles of 25 hub genes with degrees ≥10.

No.Gene symbolFull nameFunction

1OPRD1Delta-type opioid receptorPlay a role in the perception of pain and in opiate-mediated analgesia and developing analgesic tolerance to morphine.
2AVPVasopressin-neurophysin
2-copeptin
It has a direct antidiuretic action on the kidney; it also causes vasoconstriction of the peripheral vessels. Acts by binding to vasopressin receptors (V1bR/AVPR1B, V1aR/AVPR1A, and V2R/AVPR2)
3BDKRB2B2 bradykinin receptorAssociated with G proteins that activate a phosphatidylinositol-calcium second messenger system.
4TAS2R4Taste receptor type 2 member 4Encode a 7-transmembrane receptor protein, functioning as a bitter taste receptor.
5KNG1Kininogen-1A mediator of inflammation and causes increase in vascular permeability.
6BDKRB1B1 bradykinin receptorThis is a receptor for bradykinin. Could be a factor in chronic pain and inflammation.
7AGTAngiotensinogenEssential component of the renin-angiotensin system, a potent regulator of blood pressure, body fluid and electrolyte homeostasis.
8PTGDR2Prostaglandin D2 receptor 2PI3K signaling is implicated in mediating PTGDR2 effects.
9LPAR6Lysophosphatidic acid receptor 6Bind to oleoyl-L-alpha-lysophosphatidic acid (LPA). Intracellular cAMP is involved in the receptor activation.
10C5Complement C5A mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes
11OPRL1Nociceptin receptorPlay a role in the regulation of locomotor activity by the neuropeptide nociceptin.
12ADRA2CAlpha-2C adrenergic receptorAlpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.
13CCL16C-C motif chemokine 16Shows potent myelosuppressive activity and suppresses proliferation of myeloid progenitor cells.
14OXER1Oxoeicosanoid receptor 1Receptor for eicosanoids and polyunsaturated fatty acids
15CORTCortistatinBind to all human somatostatin receptor (SSTR) subtypes. It also inhibits cAMP production induced by forskolin through SSTRs.
16SSTR5Somatostatin receptor type 5Increases cell growth inhibition activity of SSTR2 following heterodimerization
17PYYPeptide YYThis gut peptide inhibits exocrine pancreatic secretion, has a vasoconstrictory action, and inhibits jejunal and colonic mobility.
18MCHR1Melanin-concentrating hormone receptor 1Receptor for melanin-concentrating hormone, coupled to both G proteins that inhibit adenylyl cyclase and G proteins that activate phosphoinositide hydrolysis.
19UTS2RUrotensin-2 receptorHigh affinity receptor for urotensin-2 and urotensin-2B.
20ANXA1Annexin A1Play important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity
21ADCY1Adenylate cyclase type 1Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Mediates responses to increased cellular Ca2+/calmodulin levels
22GPR68Ovarian cancer G-protein coupled receptor 1Proton-sensing receptor involved in pH homeostasis.
23PIK3R1Phosphatidylinositol 3-kinase regulatory subunit alphaModulates the cellular response to ER stress during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement
24P2RY4P2Y purinoceptor 4Receptor for UTP and UDP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system
25HCAR2Hydroxycarboxylic acid receptor 2Receptor activation by nicotinic acid results in reduced cAMP levels which may affect activity of cAMP-dependent protein kinase A and phosphorylation of target proteins, leading to neutrophil apoptosis.