Protective Effect of Astragaloside IV on Hepatic Injury Induced by Iron Overload
Astragaloside IV could reverse the decrease of cell activity induced by dextran iron. MTT experimental results expressed as the relative activity of the drug-administered group and the Control group. (a) Lo2 cells were individually treated with different concentrations of iron dextran. (b) Different concentrations of Astragaloside IV (As) were separately administered to Lo2 cells (DMSO was used as the mother liquid solvent and diluted 1000 times in the single culture), and 1 DMSO was added to the control group. (c) Lo2 cells were treated with Fe or/and Astragaloside IV. (d) The expression of ferritin was detected by western blot. The control group was given 1 DMSO, and the model group was given Fe alone. The treatment group was given different concentrations of Astragaloside IV followed with the 60Î¼M Fe. [ p<0.05, p<0.01, p<0.001, VS Control; # p<0.05, ## p<0.01, VS 60Fe].
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