Effects of IL-4-590C/T (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects

Table 1

Main characters of studies included in this meta-analysis.

Author	Year	Country	Ethnicity	Cancer type	Genotyping method	Case/n	Control/n	for HWE	NOS scores
Amirzargar et al. [18]	2005	Iran	Caucasian	Leukemia	PCR-SSP	30	40		6
Chang et al. [19]	2015	China	Asian	Lung cancer	PCR-RFLP	358	716		8
Chu et al. [39]	2012	China	Asian	Bladder cancer	TaqMan	816	1140	0.323	7
Chu et al. [38]	2012	China	Asian	Renal cell carcinoma	TaqMan	620	623	0.079	7
Crusius et al. [26]	2008	Netherlands	Caucasian	Gastric cancer	PCR-RFLP	242	1154	0.603	7
El-Omar et al.[20]	2003	Scotland	Mixed	Esophageal cancer	PCR-ARMS	90	209		6
El-Omar et al. [20]	2003	Scotland	Mixed	Gastric cancer	PCR-ARMS	122	209		7
Gaur et al. [27]	2011	India	Caucasian	Oral carcinoma	PCR-RFLP	140	120	0.095	8
Gu and Shen [28]	2014	China	Asian	Lung cancer	TaqMan	500	500	0.348	7
Lai et al. [29]	2005	China	Asian	Gastric cancer	PCR-RFLP	123	162	0.698	7
Li et al. [21]	2012	China	Asian	Lung cancer	PCR-RFLP	1072	1126		7
Liang et al. [30]	2010	China	Asian	Gastric cancer	PCR	238	112	0.118	7
Lu et al. [31]	2014	China	Asian	Hepatocellular cancer	PCR	154	170	0.549	7
Olson et al. [22]	2007	USA	Mixed	Prostate cancer	PCR-RFLP	149	128		8
Pan et al. [32]	2014	China	Asian	Gastric cancer	PCR	308	307	0.389	7
Saxena et al. [23]	2014	India	Caucasian	Hepatocellular cancer	TaqMan	59	153		7
Tsai et al. [40]	2005	China	Asian	Oral carcinoma	PCR-RFLP	130	105	0.741	7
Yang et al. [33]	2014	China	Asian	Oral carcinoma	PCR-RFLP	463	623	0.233	7
Zambon et al. [34]	2008	Italy	Caucasian	Gastric cancer	TaqMan	40	64	0.800	7
Ando et al. [35]	2009	Japan	Asian	Gastric cancer	TaqMan	330	190	0.248	7
Kesarwani et al. [24]	2008	India	Asian	Prostate cancer	PCR-ARMS	200	200		7
Denny et al. [36]	2018	Spanish	Caucasian	Gastric cancer	PCR-RFLP	15	20	0.814	8
Tan et al. [37]	2019	China	Asian	Lung cancer	MASSARRAY	199	266	0.195	7
Keith et al. [41]	2018	USA	Caucasian	Lung cancer	TaqMan	616	616	0.338	9
Cozar et al. [25]	2007	Spain	Caucasian	Renal cell carcinoma	RCR-RFLP	127	174	0.844	7

for HWE: value for Hardy–Weinberg equilibrium; PCR: polymerase chain reaction; RFLP: restriction fragment length polymorphism; ARMS: amplification refractory mutation system; SSP: sequence specific primers.