Review Article
Effects of IL-4-590C/T (rs2243250) Polymorphism on the Susceptibility of Smoking-Related Cancer: A Meta-Analysis Involving 11,407 Subjects
Table 3
Subgroup meta-analysis by ethnicity of IL-4 rs2243250.
| | Subgroup | Contrast model | OR (95% CI) | | Test for heterogeneity | Analysis model | | I2 (%) | |
| | Asian | C vs. T | 0.947 (0.877, 1.023) | 0.168 | 28.40 | 0.175 | F | | CC vs. TT | 1.047 (0.698, 1.571) | 0.825 | 64.90 | 0.001 | R | | CT vs. TT | 0.878 (0.798, 0.967) | 0.008 | 0.00 | 0.806 | F | | CC + CT vs. TT | 0.903 (0.824, 0.990) | 0.030 | 0.00 | 0.909 | F | | CC vs. TT + CT | 1.097 (0.726, 1.658) | 0.659 | 67.10 | 0.001 | R |
| | Caucasian | C vs. T | 1.124 (0.858, 1.471) | 0.397 | 59.90 | 0.029 | R | | CC vs. TT | 1.113 (0.763, 1.624) | 0.580 | 19.70 | 0.289 | F | | CT vs. TT | 1.259 (0.875, 1.813) | 0.215 | 0.00 | 0.487 | F | | CC + CT vs. TT | 1.341 (0.948, 1.897) | 0.097 | 11.40 | 0.341 | F | | CC vs. TT + CT | 1.046 (0.882, 1.241) | 0.605 | 42.70 | 0.121 | F |
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R: random effect model; F: fixed-effect model; OR: odds ratio; CI: confidence interval.
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