Melatonin Attenuates β-Glycerophosphate-Induced Calcification of Vascular Smooth Muscle Cells via a Wnt1/β-Catenin Signaling Pathway

Figure 6

Schematic representation showing that melatonin regulates VSMC osteogenic differentiation through a Wnt1/β-catenin signaling pathway. Melatonin decreased the expression of Wnt1, which in turn inactivated β-catenin and subsequently suppressed osteogenic differentiation. These effects subsequently attenuated VSMC calcification.