Reevaluating the Role of Corticosteroids in Septic Shock: An Updated Meta-Analysis of Randomized Controlled Trials

Table 2

Different effect-model in each subgroup analysis.

	Studies, n	Patinets, n	Random Effects	Fixed Effects	P	, %	Heterogeneity P
Overall	21	9043	0.94(0.89,1.00)	0.93(0.88,0.99)	0.05	2	0.43
Long course of low-dose corticosteroids	18	8665	0.93(0.87,0.98)	0.92(0.86,0.98)	0.01	0	0.52
Short course of high-dose corticosteroid	3	378	1.15(0.94,1.42)	1.17(0.94,1.46)	0.15	0	0.82
before 21s	6	503	0.97(0.74,1.26)	1.01(0.83,1.23)	0.03	0	0.64
after 21s	15	8540	0.93(0.88,0.99)	0.93(0.87,0.99)	0.8	0	0.16
Hydrocortisone concomitant fludrocortisone therapy	2	1540	0.88(0.78,0.99)	0.87(0.78,0.99)	0.03	0	0.79
Hydrocortisone alone therapy	14	7072	0.95(0.89,1.02)	0.94(0.87,1.01)	0.09	0	0.49
Sample size≥400	3	6594	0.90(0.83,0.97)	0.90(0.83,0.98)	<0.001	0	0.67
Sample size<400	18	2448	0.99(0.91,1.08)	0.99(0.90,1.08)	0.77	0	0.46