Aberrant Expression of EZH2 in Pediatric Patients with Myelodysplastic Syndrome: A Potential Biomarker of Leukemic Evolution

Table 1

Clinical and cytogenetics characteristics of pediatric patients with primary MDS.

Clinical characteristics	Number of Patients (%)
Age
Mean of age: 8 years old (range from 5 months to 18 years)	42 (100%)
Sex
Male	27 (64%)
Female	15 (36%)
MDS subtypes
Initial subtype: RCC	22 (52%)
Advanced subtypes
RAEB	15 (36%)
RAEB-t	5 (12%)
Karyotypes
Normal	18 (43%)
Abnormal	24 (57%)
del(4q)	1 (2.4%)
Trisomy 6	1 (2.4%)
del(7q)	3 (7.1%)
Monosomy 7	5 (12%)
Trisomy 8	3 (7.1%)
del(9q)	1 (2.4%)
del(11q)	3 (7.1%)
del(12p)	1 (2.4%)
del(17p)	1 (2.4%)
Trisomy 14	1 (2.4%)
Marker chromosome	1 (2.4%)
Complex karyotype	3 (7.1%)