Treatment-Related Prognostic Factors in Managing Osteosarcoma around the Knee with Limb Salvage Surgery: A Lesson from a Long-Term Follow-Up Study

Table 1

Patient characteristics.

	Number of patients (%)
Gender
female	68(37.4%)
male	114(62.6%)
Age at diagnosis	21.2±7.6 years, 12-59
31-59 years old	29(15.9%)
21-30 years old	50(27.5%)
10-20 years old	103(56.6%)
Site
distal femur	118(64.8%)
proximal tibia	64(35.2%)
Symptom intervals	68.2±69.7 days, 23-750
<60 days	84(46.2%)
>=60 days	98(53.8%)
Pathologic fracture
not occurred	174(95.6%)
occurred	8(4.4%)
Center performing the biopsy/the tumor resection
same	151(83%)
different	31(17%)
Previous medical history
no	165(90.7%)
yes	17(9.3%)
Elevated initial ALP
no	42(23.1%)
yes	140(76.9%)
Bone margin width
>=3 cm	161(88.5%)
>=2 cm	21(11.5%)
Neurovascular infiltration
no	122(67%)
yes	60 (33%)
Tumor size
<10 cm	106(58.2%)
>=10 cm	76(41.8%)
Histological subtypes
osteoblastic	134(73.6%)
chondroblastic	24(13%)
fibroblastic	10(5.5%)
telengiectatic and other	14(7.9%)
Tumor necrosis
>=90%	70(38.5%)
<90%	112(61.5%)
Preoperative chemotherapy duration	10.8 ± 2.1weeks, 4-16
8-12 weeks	110(60.4%)
>12 weeks	38(20.9%)
<8 weeks	34(18.7%)
Preoperative interval	13.1 ± 4.1days, 7-25
<14 days	104(57.1%)
>=14 days	78(42.9%)
Postoperative interval	23±10.1 days, 7-60
<=14 days	30(16.5%)
15-21days	75(41.2%)
>21 days	77(42.3%)