Treatment-Related Prognostic Factors in Managing Osteosarcoma around the Knee with Limb Salvage Surgery: A Lesson from a Long-Term Follow-Up Study

Table 3

Summary of univariate and multivariate Cox proportional hazards models for LR. HR: hazards ratio; LRT: likelihood rate testing.

	Univariate LRT		Multivariate LRT
	p values and HR (95%)		p values and HR (95%)
Gender	0.241
female	Ref.
male	0.625(0.285-1.370)
Age at diagnosis	0.544
31-59 years old	Ref.
21-30 years old	1.947(0.527-7.194)
10-20 years old	1.366(0.389-4.794)
Site	0.678
distal femur	Ref.
proximal tibia	0.837(0.361-1.940)
Symptom intervals	0.480
<60 days	Ref.
>=60 days	1.334(0.599-2.971)
Pathologic fracture	0.464
not occurred	Ref.
occurred	0.046(0-171.359)
Center performing the biopsy/the tumor resection	<0.001		0.002
same	Ref.		Ref.
different	4.601(2.082-10.169)		4.099(1.649-10.192)
Previous medical history	0.060		0.931
no	Ref.		Ref.
yes	2.561(0.960-6.835)		0.951(0.308-2.942)
Initial raised ALP	0.301
no	Ref.
yes	1.517(0.688-3.344 )
Bone margin width	0.895
>=3 cm	Ref.
>=2 cm	1.084(0.325-3.624)
Neurovascular infiltration	0.007		0.163
no	Ref.		Ref.
yes	4.140(1.826-9.388)		1.838(0.782-4.320)
Tumor size	0.070		0.152
<10 cm	Ref.		Ref.
>=10 cm	2.080(0.043-4.589)		1.871(0.795-4.405)
Histological subtypes	0.340
osteoblastic	Ref.
chondroblastic	0.261(0.035-1.944)
fibroblastic	1.922(0.571-6.470)
telengiectatic and other	0.477(0.064-3.555)
Tumor necrosis	0.014		0.022
>=90%	Ref.		Ref.
<90%	3.802(1.304-11.087)		3.536(1.198-10.438)
Preoperative chemotherapy duration	0.783
8-12 weeks	Ref.
>12 weeks	0.694(0.234-2.063)
<8 weeks	0.818(0.275-2.432)
Preoperative interval	0.336
<14 days	Ref.
>=14 days	1.469(0.670-3.220)
Postoperative interval	0.761
<=14 days	Ref.
15-21days	0.934(0.288-3.034)
>21 days	1.278(0.412-3.964)