N-Methyl-N-Nitrosourea-Induced Photoreceptor Degeneration Is Inhibited by Nicotinamide via the Blockade of Upstream Events before the Phosphorylation of Signalling Proteins
Photoreceptor degeneration induced by intraperitoneal MNU injection. OCT images were obtained from rats before and after administration of MNU, NAM, or MNU/NAM (a). The thickness of the photoreceptor layer (arrow) was measured (b). The photoreceptor layer (arrow) was present in the retina during MNU preadministration. The photoreceptor layer became thicker 6 hours after MNU injection and then gradually thinner at later time points. Data are shown as mean ± standard error (n = 4–16, ,: p < 0.05, 0.001, Tukey’s multiple comparison test). MNU: N-methyl-N-nitrosourea; NAM: nicotinamide; and OCT: optical coherence tomography.
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