Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

Table 1

Summary of effects of platelet-rich fibrin on stem cells.

Cell type	Intervention	Outcome	Reference
Rat GSPCs	PRF	Increased CBF-α1 expression	[27]
Rat PDLSCs	Cell culture: PRF; surgical procedure: implanted PRF membrane and rat PDLSCs	Increased cell proliferation and enhanced ALP activity and OC, RUNX2, and BSP mRNA and protein levels; promoted expressions of COL1A, Opn, and RUNX2 with enhanced new alveolar and mandibular bone	[28]
Human osteoblasts	PRF	Enhanced lactate dehydrogenase test values, cell growth, proliferation, and alkaline phosphatase activity	[23]
Human periodontal progenitors: PDL, DF, AB	PRF with 10% FBS	Increased cell proliferation, migration, alkaline phosphatase, alizarin red staining, and expression of RUNX2, but reduced expression of MGP	[29]
Human PDLSCs	PRF	Induced cell proliferation but decreased ALP activity and gene expressions of BSP and OCN	[30]

DF: dental follicle progenitors; FBS: fetal bovine serum.