Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

Table 3

Summary of clinical effects of platelet-rich fibrin alone on oral and maxillofacial bone regeneration.

Patient number (age/range)	Disease type	Intervention	Follow-up	Outcome	Reference
1 (59 years)	Atrophy of maxillary posterior edentulous areas	PRF was filled after maxillary sinus floor elevation	6 m	Bone formation was seen radiologically and histologically	[37]
27 (29−74 years)	Atrophy of maxillary posterior edentulous areas	PRF was filled after maxillary sinus floor elevation	12 m	Bone gains were 4.38 mm and 4 mm in the SA and HA groups radiologically	[38]
10 (23−45 years)	IBD	PRF	6 m	Complete bone formation was seen radiologically	[39]
20 (20−55 years)	IBD	PRF	6 m	Complete bone formation was seen radiologically	[40]
2 (24 years and 32 years)	IBD	PRF	9 m	Considerable bone fill was seen radiologically	[41]
15 (20−50 years)	IBD	PRF	6 m	Complete bone fill was seen radiologically	[42]
1 (12 years)	IBD	PRF	6 m	Complete bone fill was seen radiologically	[43]
20 (18−50 years)	Extraction of teeth (40 sites)	PRF	3 m	Increased bone density radiologically	[44]
28 (20−40 years)	Extraction of teeth	PRF	3 m	Enhanced bone gain histologically	[45]
30 (20−50 years)	Extraction of teeth (60 sites)	PRF	30 m	Enhanced bone density histologically	[46]
20 (18−28 years)	Extraction of teeth (40 sites)	PRF or PRP	4 m	Increased bone density radiologically	[47]
20 (19−34 years)	Extraction of teeth (40 sites)	PRF	3 m	No significant difference in bone density	[48]
34 (18−40 years)	Extraction of teeth (68 sites)	PRF	6 m	No significant difference in bone quantity	[49]
30 (18−30 years)	Extraction of teeth	PRF or PRP	6 m	No significant difference in bone density	[50]
13 (35−55 years)	IBD (26 sites)	PRF	12 m	Increased bone fill percentage radiologically	[51]
17 (20−30 years)	IBD (54 sites)	PRF	9 m	Increased IBD depth change radiologically	[52]
15 (28−44 years)	Horizontal bony defects (45 sites)	PRF	9 m	No significant difference in RCH radiologically	[53]
40 (17−36 years)	Extraction teeth	PRP or PRF or HA	6 m	Lesser bone density values were seen in PRP, PRF, and control site at 1, 2, and 6 months than at the HA site radiologically	[54]
20 (30−55 years)	IBD	PRF or ABG	9 m	ABG showed greater RBF as compared with PRF	[55]

RCH: relative bone crest height; RBF: radiographic bone fill.