|
| Patient number (age/range) | Disease type | Intervention | Follow-up | Outcome | Reference |
|
| 1 (45 years) | Periapical bony defect | PRF and HA | 24 m | New bone replaced HA almost completely radiographically | [58] |
| 3-case report (19−24 years) | Periapical bony defect | PRF and HA | 12 m | New bone replaced HA radiographically | [59] |
| 1 (35 years) | IBD | PRF and Bio-Oss | 1 8 m | Increased radiographic bone fill | [60] |
| 1 (25 years) | IBD | PRF and HABG | 12 m | Complete healing of the defect radiographically | [61] |
| 4-case report (43−59 years) | Atrophy of maxillary posterior edentulous areas | PRF and DBBM were filled after maxillary sinus augmentation | 7 m or 10 m | Mean percentage of new bone was 34.5% ± 5.7% histomorphometrically | [62] |
| 1 (59 years) | Atrophy of maxillary posterior edentulous areas | PRF and DBBM were filled after maxillary sinus augmentation | 8 m | More newly formed bone than by using DBBM alone histomorphometrically | [63] |
| 14-case report (—) | Atrophy of maxillary posterior edentulous areas (30 sites) | PRF and Bio-Oss were filled after maxillary sinus augmentation | 6 m | Mean vertical bone height gain was 10.12 mm radiographically | [64] |
| 1 (38 years) | Extraction of teeth | PRF and Bio-Oss | 6 m | New bone regeneration around the neck of the implant radiographically | [65] |
| 57 (mean age: 39.7 years) | IBD (90 sites) | Group I : PRF + OFD; group II : PRF + HA + OFD; group III : OFD | 9 m | Percentage of mean bone fill radiographically in group I was 56.46% ± 9.26%, in group II was 63.39% ± 16.52%, and in group III was 15.96% ± 13.91% | [66] |
| 17 (mean age: 44 ± 9 years) | IBD (34 sites) | PRF or PRF-BPBM combination | 6 m | Defect fill was greater in the PRF-BPBM group radiographically | [67] |
| 36 (30−50 years) | IBD | Group I : PRF + DBM; group II : PRF; group III : OFD | 9 m | Significant improvement in LBG and %BF was found in group I radiographically () | [68] |
| 15 (mean age: 36.1 years) | Grade II furcation defects (30 sites) | Group I : PRF and amnion membrane; group II : PRF | 6 m | More volumetric bone gain and radiographic linear bone growth was seen in group I | [69] |
| 10 (20−50 years) | IBD (20 sites) | PRF and bioactive glass putty (test group) or bioactive glass putty alone (control group) | 9 m | The radiographic bone fill from baseline at the control site was 5.70 ± 1.64 and that at the test site was 7.10 ± 1.37 () | [70] |
| 16 (25−65 years) | Class II furcation defects (20 sites) | PRF and BCCG (test sites) or BCCG alone (control sites) | 6 m | More percentage defect fill was seen in the test group (). Increase in radiographic bone density at the furcation defect in the test group () | [71] |
| 20 (27−45 years) | IBD (40 sites) | Group I : BG + PRF; group II : BG alone | 6 m | More defect depth reduction was seen in group I () radiographically | [72] |
| 6 dogs (adult) | Atrophy of maxillary posterior edentulous areas (12 sites) | Group I : PRF and Bio-Oss; group II : Tisseel and Bio-Oss was filled after maxillary sinus augmentation | 6 m | The mean new bone formation rate was 41.8 ± 5.9% in group I, and in group II, it was 31.3 ± 6.4% () radiographically | [73] |
| 12 (43−63 years) | Atrophy of maxillary posterior edentulous areas (38 sites) | DBBM + L‐PRF (test) or DBBM alone (control) was filled after maxillary sinus augmentation | 4 m (test), 8 m (control) | Newly formed bone in the test group was 44.58% ± 13.9% and that in the control group was 30.02% ± 8.42%; on histological evaluation | [74] |
| 15 (38−61 years) | IBD (30 sites) | ABBM (control group) or ABBM-PRF combination (test group) | 6 m | Defect fill was not statistically different radiographically | [75] |
| 28 (age ≥18) | IBD (56 sites) | IBDs were randomly treated either with EMD or with EMD + PRF | 6 m | Defect fill was not statistically different radiographically | [76] |
| 10 (—) | IBD (20 sites) | Group I : DFDBA; group II: mixture of PRF with DFDBA | 6 m | Mean defect fill and mean defect resolution were not statistically different radiographically | [77] |
| 13 (35−65 years) | Atrophy of maxillary posterior edentulous areas (26 sites) | DBBM and PRF mixture (test) or DBBM (control) was filled after maxillary sinus augmentation | 6 m | Newly formed bone was similar () | [78] |
| 22 (6−28 years) | Alveolar cleft (13 unilateral and 9 bilateral) | Group A: autogenous bone grafts; group B: autogenous bone grafts with PRF | 6 m | Percentages of newly formed bone were similar () | [79] |
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