Platelet-Rich Fibrin as a Bone Graft Material in Oral and Maxillofacial Bone Regeneration: Classification and Summary for Better Application

Table 6

Summary of clinical effects of modified platelet-rich fibrin in combination in oral and maxillofacial bone regeneration.

Patient number (age/range)	Disease type	Intervention	Follow-up	Outcome	Reference
1 (61 years)	Bony defect within the mandible	Solid A-PRF and liquid I-PRF together with an individualized 3D planned titanium mesh	8 m	New bone originated from the residual bone on histological analysis, while oral function complete rehabilitation and restoration	[98]
1 (36 years)	IBD	A-PRF and I-PRF, which were mixed with Bio-Oss and packed onto the 3D replica	15 m	Significant radiographic 3D alveolar bone fill	[99]
18 (42−69 years)	Atrophy of maxillary posterior edentulous areas	T-PRF or allografts	6 m	Bone formation after 6 months of allografts was achieved in the T-PRF group at only 4 months radiologically and histologically	[101]
38 (20−55 years)	IBD (90 sites)	PRF or T-PRF	9 m	No statistically significant difference in defect depth reduction	[102]