Research Article
Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women
Table 1
Characteristics of cases and controls.
| Variables | Cases (n = 818) | Controls (n = 935) | value | N (%) | N (%) |
| Age (mean ± SD, year) | 54.78 ± 11.10 | 54.27 ± 11.30 | 0.337 | <53 | 393 (48.04) | 458 (48.98) | 0.730b | ≥53 | 425 (51.96) | 477 (51.02) | |
| Age at menarche (mean ± SD, year) | 15.52 ± 2.55 | 15.48 ± 2.73 | 0.762a | Age at first live birth (mean ± SD, year) | 24.60 ± 2.70 | 24.58 ± 2.48 | 0.875a | Chest circumference (mean ± SD, cm) | 90.40 ± 8.69 | 90.70 ± 7.90 | 0.451a | Age at menopause (mean ± SD, year) | 49.18 ± 4.87 | 49.29 ± 6.04 | 0.727a | Waist circumference (mean ± SD, cm) | 87.31 ± 10.98 | 83.07 ± 9.84 | <0.001a |
| Menopausal status at baseline | | | | Premenopausal | 214 (26.16) | 385 (41.22) | <0.001b | Postmenopausal | 604 (73.84) | 549 (58.78) |
| Body mass index (mean ± SD, kg/m2) | 24.93 ± 3.54 | 24.14 ± 3.16 | <0.001a | <18.5 | 19 (2.35) | 15 (1.60) | <0.001b | 18.5–23.9 | 325 (40.17) | 471 (50.37) | 24.0–27.9 | 330 (40.79) | 339 (36.26) | ≥28.0 | 135 (16.69) | 110 (11.77) |
| Education | | | | Primary school | 256 (31.33) | 228 (24.44) | <0.001b | Junior middle school | 348 (42.60) | 341 (36.55) | Senior middle school | 148 (18.12) | 225 (24.12) | University and above | 65 (7.96) | 139 (14.90) |
| Income (yuan) | | | | <30000 | 216 (26.54) | 149 (15.94) | <0.001b | 30000–49999 | 163 (20.02) | 121 (12.94) | 50000–100000 | 265 (32.56) | 317 (33.90) | ≥100000 | 170 (20.88) | 348 (37.22) |
| Oral contraceptive use | | | | No | 652 (80.10) | 760 (82.16) | 0.299b | Yes | 162 (19.90) | 165 (17.84) |
| Family history of breast cancer | | | | No | 711 (88.76) | 873 (94.38) | <0.001b | Yes | 90 (11.24) | 52 (5.62) |
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aWelch’s t-test was applied for the unequal variances. bTwo-sided chi-square test.
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