Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women
Table 2
Summary of associations between genetic variants and breast cancer risk.
Genotype
Cases
Controls
Crude OR (95% CI)
Adjusted OR (95% CI)b
b
rs16847024 (C > T)a
CC
612
708
1.00
1.00
CT
175
203
1.00 (0.79–1.26)
0.93 (0.73–1.19)
0.556
TT
13
14
0.99 (0.46–2.16)
0.97 (0.43–2.22)
0.946
CT/TT
188
217
1.00 (0.80–1.25)
0.93 (0.73–1.18)
0.562
Additive model
1.00 (0.81–1.22)
0.94 (0.76–1.17)
0.594
rs17467825 (A > G)
AA
377
402
1.00
1.00
AG
325
414
0.83 (0.68–1.02)
0.77 (0.62–0.96)
0.020
GG
89
93
1.02 (0.74–1.41)
0.95 (0.67–1.35)
0.785
AG/GG
414
507
0.87 (0.72–1.05)
0.80 (0.65–0.99)
0.039
Additive model
0.95 (0.82–1.09)
0.90 (0.77–1.05)
0.181
rs2298850 (G> C)
GG
367
393
1.00
1.00
GC
341
428
0.85 (0.69–1.04)
0.78 (0.63–0.97)
0.025
CC
89
99
0.96 (0.70–1.33)
0.89 (0.63–1.27)
0.530
GC/CC
430
527
0.87 (0.72–1.05)
0.80 (0.65–0.98)
0.035
Additive model
0.93 (0.81–1.08)
0.89 (0.76–1.03)
0.123
rs3755967 (C > T)
CC
372
396
1.00
1.00
CT
332
420
0.84 (0.68–1.02)
0.77 (0.62–0.96)
0.021
TT
90
97
0.99 (0.72–1.36)
0.92 (0.65–1.30)
0.627
CT/TT
422
517
0.86 (0.71–1.05)
0.80 (0.65–0.98)
0.035
Additive model
0.94 (0.81–1.08)
0.89 (0.76–1.04)
0.143
aMajor allele > minor allele. bDerived from logistic regression with an adjustment for age, menopausal status, BMI, family history, income, waist circumference, and education. OR, odds ratio.
