Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women
Table 3
Stratified analyses of association between 4 SNPs and breast cancer risk.
Age (years)
Menopausal status
Family history
Waist circumference (cm)
<53
≥53
Premenopause
Postmenopause
No
Yes
<80
≥80
rs16847024 (C > T)
OR (95% CI)a
1.00 (0.72–1.38)
0.95 (0.70–1.27)
1.01 (0.69–1.48)
0.92 (0.70–1.20)
0.94 (0.75–1.18)
1.18 (0.50–2.77)
1.04 (0.68–1.58)
0.95 (0.73–1.22)
valuea
0.983
0.720
0.957
0.517
0.588
0.702
0.863
0.670
for heterogeneity
0.832
0.226
0.613
0.719
rs17467825 (A > G)
OR (95% CI)a
0.84 (0.67–1.06)
0.97 (0.78–1.20)
0.86 (0.65-1-1.14)
0.95 (0.79–1.14)
0.87 (0.74–1.02)
1.23 (0.66–2.28)
0.69 (0.51–0.93)
1.01 (0.84–1.21)
valuea
0.135
0.775
0.289
0.565
0.09
0.512
0.015
0.919
for heterogeneity
0.369
0.560
0.289
0.035
rs2298850 (G > C)
OR (95% CI)a
0.83 (0.66–1.04)
0.95 (0.77–1.18)
0.86 (0.65–1.13)
0.93 (0.78–1.12)
0.85 (0.73–1.00)
1.23 (0.66–2.27)
0.66 (0.49–0.89)
1.01 (0.84–1.21)
valuea
0.111
0.664
0.271
0.475
0.057
0.512
0.006
0.956
for heterogeneity
0.398
0.644
0.255
0.019
rs3755967 (C > T)
OR (95% CI)a
0.82 (0.65–1.03)
0.98 (0.79–1.21)
0.84 (0.64–1.11)
0.95 (0.79–1.14)
0.86 (0.73–1.01)
1.22 (0.66–2.26)
0.67 (0.50–0.91)
1.01 (0.84–1.21)
valuea
0.09
0.841
0.226
0.559
0.069
0.532
0.009
0.932
for heterogeneity
0.265
0.470
0.284
0.023
aOR with its 95% CI and value were derived from the additive model (wild-type homozygote vs. heterozygote vs. variant homozygote) using logistic regression adjusted for age, menopausal status, BMI, family history, income, waist circumference, and education.
