Genetic Variants in Group-Specific Component (GC) Gene Are Associated with Breast Cancer Risk among Chinese Women

Table 4

Interaction analysis between three SNPs genotypes and waist circumference on breast cancer risk.

Genotypes	Waist circumference (cm)	Cases	Controls	Crude OR (95% CI)	Adjusted OR (95% CI)^a
rs17467825
AA	≥80	283 (35.8%)	255 (28.1%)	1.00	1.00
AA	<80	94 (11.9%)	147 (16.2%)	0.58 (0.43–0.79)	0.69 (0.49–0.98)	0.037
AG	≥80	249 (31.5%)	259 (28.5%)	0.86 (0.68–1.10)	0.85 (0.66–1.09)	0.203
AG	<80	76 (9.6%)	155 (17.1%)	0.44 (0.32–0.61)	0.46 (0.31–0.66)	<0.001
GG	≥80	71 (9.0%)	49 (5.4%)	1.31 (0.87–1.95)	1.22 (0.80–1.87)	0.342
GG	<80	18 (2.3%)	44 (4.8%)	0.37 (0.21–0.65)	0.40 (0.21–0.75)	0.004
for multiplicative interaction						0.057
rs2298850
GG	≥80	272 (34.1%)	251 (27.3%)	1.00	1.00
GG	<80	95 (11.9%)	142 (15.4%)	0.62 (0.46–0.85)	0.72 (0.51–1.03)	0.069
GC	≥80	264 (33.1%)	270 (29.3%)	0.90 (0.71–1.14)	0.87 (0.67–1.12)	0.280
GC	<80	77 (9.7%)	158 (17.2%)	0.45 (0.32–0.62)	0.46 (0.32–0.67)	<0.001
CC	≥80	71 (8.9%)	51 (5.5%)	1.29 (0.87–1.92)	1.18 (0.77–1.79)	0.443
CC	<80	18 (2.3%)	48 (5.2%)	0.35 (0.20–0.61)	0.37 (0.20–0.70)	0.002
for multiplicative interaction						0.031
rs3755967
CC	≥80	277 (34.9%)	252 (27.6%)	1.00	1.00
CC	<80	95 (12.0%)	144 (15.8%)	0.61 (0.44–0.83)	0.7 (0.49–0.99)	0.045
CT	≥80	257 (32.4%)	267 (29.2%)	0.87 (0.68–1.11)	0.85 (0.66–1.10)	0.222
CT	<80	75 (9.4%)	153 (16.8%)	0.44 (0.32–0.62)	0.46 (0.32–0.67)	<0.001
TT	≥80	72 (9.1%)	50 (5.5%)	1.31 (0.88–1.95)	1.21 (0.79–1.84)	0.379
TT	<80	18 (2.2%)	47 (5.1%)	0.35 (0.20–0.62)	0.37 (0.20–0.70)	0.002
for multiplicative interaction						0.039

^aAdjusted by age, menopausal status, BMI, family history, income, and education.