Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2<i>α</i>/ATF4 and IRE1<i>α</i>

<div>Mechanism of action of EGCG in colorectal cancer (CRC). ER stress is induced by EGCG and activates UPR proteins, PERK (with its downstream targets eIF2<i>α</i> and ATF4), and IRE1<i>α</i>. Caspase 3/7 activity is also enhanced, indicating apoptosis occurrence in the colorectal cancer cells.</div>

BioMed Research International

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Figure 6

Figure 6: Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2<i>α</i>/ATF4 and IRE1<i>α</i> 

Figure 6 | Induction of Endoplasmic Reticulum Stress Pathway by Green Tea Epigallocatechin-3-Gallate (EGCG) in Colorectal Cancer Cells: Activation of PERK/p-eIF2α/ATF4 and IRE1α 