Identification of Key Genes and Pathways Associated with Sex Differences in Osteoarthritis Based on Bioinformatics Analysis

Table 1

The top 20 GO enrichment analysis of the overlapping DEGs associated with sex in OA.

GO term	Biological function	Gene count	value
GO:0045944	Positive regulation of transcription from RNA polymerase II promoter	26	3.86E − 03
GO:0007165	Signal transduction	26	2.76E − 02
GO:0007155	Cell adhesion	19	1.18E − 04
GO:0045893	Positive regulation of transcription, DNA-templated	16	7.62E − 03
GO:0006468	Protein phosphorylation	15	6.31E − 03
GO:0043547	Positive regulation of GTPase activity	15	3.39E − 02
GO:0008284	Positive regulation of cell proliferation	14	1.75E − 02
GO:0045892	Negative regulation of transcription, DNA-templated	14	2.80E − 02
GO:0045087	Innate immune response	12	4.65E − 02
GO:0007507	Heart development	10	1.33E − 03
GO:0007268	Chemical synaptic transmission	9	2.28E − 02
GO:0001666	Response to hypoxia	8	1.22E − 02
GO:0048015	Phosphatidylinositol-mediated signaling	7	4.25E − 03
GO:0071356	Cellular response to tumor necrosis factor	7	5.09E − 03
GO:0018108	Peptidyl-tyrosine phosphorylation	7	2.32E − 02
GO:0001701	In utero embryonic development	7	5.29E − 02
GO:0014068	Positive regulation of phosphatidylinositol 3-kinase signaling	6	2.40E − 03
GO:0014066	Regulation of phosphatidylinositol 3-kinase signaling	6	5.27E − 03
GO:0042060	Wound healing	6	5.86E − 03
GO:0030307	Positive regulation of cell growth	6	7.19E − 03