The Role of Rhodomyrtus tomentosa (Aiton) Hassk. Fruits in Downregulation of Mast Cells-Mediated Allergic Responses
Figure 2
The suppressive effect of RFE on cytokine productions in calcium ionophore A23187-activated RBL-2H3 mast cells. Cells were pretreated with various concentrations of RFE for 24 h before exposure to A23187 for 1 h. The production level of IL-1β (a) and TNF-α (b) was quantified in culture media using commercial ELISA kits. Each determination was made in three independent experiments, and the data are shown as means ± SD. Different letters A–D indicate significant difference among groups (p < 0.05) by Duncan’s multiple-range test. The same letter indicates that the difference between the means is not statistically significant. If two groups have different letters, they are significantly different from each other at p < 0.05. If a group is similar to A and B or B and C, it was addressed by letters “AB” or “BC,” respectively.