Review Article
Body Mass Index and the Risk of Rheumatoid Arthritis: An Updated Dose-Response Meta-Analysis
Table 2
Subgroup analyses of BMI and rheumatoid arthritis risk.
| | Study | overweight | obesity | | No. of studies | OR RR (95%CI) | I2(%) | No. of studies | OR RR (95%CI) | I2(%) |
| | All studies | 15 | 1.12(1.04-1.20) | 10.9 | 15 | 1.23(1.09-1.39) | 45.5 | | Sex | | | | | | | | Men | 5 | 0.94(0.79-1.12) | 1.9 | 5 | 0.87(0.55-1.38) | 60.7 | | Women | 8 | 1.16(1.05-1.29) | 23.2 | 8 | 1.30(1.13-1.49) | 39.1 | | Combined | 6 | 1.14(0.98-1.33) | 0 | 6 | 1.14(0.98-1.33) | 0 | | Study location | | | | | | | | Asia | 2 | 1.12(0.81-1.56) | 32.4 | 1 | 1.02(0.55-1.89) | 0 | | Europe | 10 | 1.07(0.98-1.17) | 0 | 10 | 1.20(1.00-1.43) | 53.3 | | North America | 3 | 1.18(0.97-1.45) | 51.7 | 4 | 1.27(1.10-1.48) | 28.3 | | NOS | | | | | | | | <7 | 1 | 1.07(0.74-1.55) | 35.9 | 2 | 1.28(1.06-1.54) | 0 | | ≥7 | 14 | 1.12(1.04-1.21) | 13 | 13 | 1.21(1.05-1.39) | 50.3 | | type | | | | | | | | case-control | 10 | 1.09(1.00-1.19) | 0 | 10 | 1.22(1.05-1.40) | 39.4 | | cohort | 5 | 1.14(0.96-1.35) | 53.1 | 5 | 1.24(0.96-1.61) | 64.3 | | Assessment method of weight/height | | | | | | | | Self-reported | 10 | 1.07(0.97-1.17) | 0 | 9 | 1.28(1.09-1.52) | 44.7 | | Measured | 5 | 1.15(0.97-1.37) | 53.8 | 6 | 1.16(0.96-1.40) | 50.9 | | Adjustment factors | | | | | | | | Age | | | | | | | | Yes | 11 | 1.12(1.04-1.21) | 6.3 | 12 | 1.23(1.08-1.39) | 47.1 | | No | 4 | 1.09(0.88-1.34) | 32.1 | 3 | 1.15(0.70-1.90) | 48.6 | | Smoking | | | | | | | | Yes | 11 | 1.12(1.02-1.22) | 21.6 | 12 | 1.24(1.08-1.42) | 49.4 | | No | 4 | 1.11(0.95-1.30) | 0 | 3 | 1.13(0.86-1.49) | 21.4 | | Alcohol consumption | | | | | | | | Yes | 5 | 1.13(0.99-1.28) | 43.5 | 5 | 1.18(0.98-1.42) | 57.1 | | No | 10 | 1.10(0.99-1.22) | 0 | 10 | 1.27(1.08-1.49) | 33.7 |
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BMI, body mass index; RR, relative risk; CI, confidence interval.
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