BioMed Research International / 2019 / Article / Tab 1

Research Article

Technical Verification and Assessment of Independent Validation of Biomarker Models for Endometriosis

Table 1

Clinical characteristics of selected patients in the technical verification and validation study.

Technical verification studyValidation study
ControlEndometriosisP-valueControlEndometriosisP-value

Numbersn = 37n = 99n = 86n = 170
(US-negative n = 81)(US-negative n = 116)

Age (years)
Mean ± SD30.8 ± 5.231.7 ± 4.00.406330.3 ± 5.331.0 ± 4.60.1411
Median, range31, 19-4431, 24-4230, 18-4231, 14-42

Symptoms (n)
Subfertility3593 (76)0.885170148 (102)0.2287
Dysmenorrhea2466 (54)0.843353137 (95)0.0011
Dyspareunia730 (22)0.18432648 (31)0.7392
Chronic pelvic pain27 (6)0.72811237 (31)0.1335
Dyschezia311 (6)0.60801117 (10)0.4992

Cycle phase (n)
Menstrual1019 (15)0.32081731 (20)0.7667
Follicular1342 (37)0.44082942 (30)0.1281
Luteal1438 (29)0.95352555 (44)0.5925
Medication//N/A1542 (22)0.1870

Stage (n)
Stages I-IIN/A71 (71)N/AN/A101 (92)N/A
Stages III-IV28 (10)69 (24)

Other pelvic pathologies (n)
Non-endometriotic adhesions12/N/A26/N/A
Myoma56 (6)0.156079 (5)0.3744
Parasalpingeal cyst1014 (14)0.079424 (4)0.9891
Hydrosalpinx42 (2)0.026351 (1)0.0090

N/A = not applicable
The patients in the technical verification study are a subset of the patient cohort that had been selected by Vodolazkaia et al.
A Mann-Whitney test was used for comparison of endometriosis cases versus controls for continuous variables (age) and chi-square test for categorical variables

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