Technical Verification and Assessment of Independent Validation of Biomarker Models for Endometriosis
Table 1
Clinical characteristics of selected patients in the technical verification and validation study.
Technical verification study
Validation study
Control
Endometriosis
P-value
Control
Endometriosis
P-value
Numbers
n = 37
n = 99
n = 86
n = 170
(US-negative n = 81)
(US-negative n = 116)
Age (years)
Mean ± SD
30.8 ± 5.2
31.7 ± 4.0
0.4063
30.3 ± 5.3
31.0 ± 4.6
0.1411
Median, range
31, 19-44
31, 24-42
30, 18-42
31, 14-42
Symptoms (n)
Subfertility
35
93 (76)
0.8851
70
148 (102)
0.2287
Dysmenorrhea
24
66 (54)
0.8433
53
137 (95)
0.0011
Dyspareunia
7
30 (22)
0.1843
26
48 (31)
0.7392
Chronic pelvic pain
2
7 (6)
0.7281
12
37 (31)
0.1335
Dyschezia
3
11 (6)
0.6080
11
17 (10)
0.4992
Cycle phase (n)
Menstrual
10
19 (15)
0.3208
17
31 (20)
0.7667
Follicular
13
42 (37)
0.4408
29
42 (30)
0.1281
Luteal
14
38 (29)
0.9535
25
55 (44)
0.5925
Medication
/
/
N/A
15
42 (22)
0.1870
Stage (n)
Stages I-II
N/A
71 (71)
N/A
N/A
101 (92)
N/A
Stages III-IV
28 (10)
69 (24)
Other pelvic pathologies (n)
Non-endometriotic adhesions
12
/
N/A
26
/
N/A
Myoma
5
6 (6)
0.1560
7
9 (5)
0.3744
Parasalpingeal cyst
10
14 (14)
0.0794
2
4 (4)
0.9891
Hydrosalpinx
4
2 (2)
0.0263
5
1 (1)
0.0090
N/A = not applicable The patients in the technical verification study are a subset of the patient cohort that had been selected by Vodolazkaia et al. A Mann-Whitney test was used for comparison of endometriosis cases versus controls for continuous variables (age) and chi-square test for categorical variables
