Antitumor Effect of Albendazole on Cutaneous Squamous Cell Carcinoma (SCC) Cells

Figure 3

Albendazole induces apoptosis of SCC cells. (a) SCC12 and SCC13 were treated with albendazole at the indicated concentrations for 24 h. TUNEL staining was performed to detect apoptosis. Albendazole significantly increased the TUNEL-positive cells in a dose-dependent manner. (b) SCC12 and SCC13 were treated with albendazole for 24h. The protein levels of cleaved PARP-1 and caspase-3 were detected by Western blot. β-Actin was used for internal control. Cleavage of PARP-1 and caspase-3 increased significantly by albendazole treatment.

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