Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics

Table 1

154 DEGs were extracted from 2 microarray data GSE6475 and GSE53795, including 145 up-regulated genes and 9 down-regulated genes in acne lesions, comparing to normal skin of acne patients.

DEGs	Gene symbol
Up-regulated genes	DEFB4B, DEFB4A, SERPINB4, MMP1, CXCL8, MMP3, CXCL1, APOBEC3A, S100A12, PI3, SPP1, AKR1B10, BCL2A1, CXCL2, MMP12, SERPINB3, LILRB2, SPRR2C, FPR1, FCGR1B, PLA2G2A, PTX3, TCN1, SERPINA1, SELE, MT1M, GZMB, CCR1, C5AR1, SOD2, MMP10, CCL19, IL36G, S100A9, SAMSN1, FCGR1CP, FCGR1A, SERPINB1, FCGR3B, FCGR3A, FCN1, CLEC7A, SELL, TREM1, PLAUR, FCER1G, KYNU, SPRR2B, GREM1, NAMPT, CFB, NNMT, CD163, IGSF6, IL7R, PLAC8, FPR2, IFI30, PIK3R2, RGS1, SAA2, SAA1, CXCR4, RHCG, PLEK, ADGRE2, SLC6A14, SRGN, LYN, GPR65, FCGR2A, IL1B, S100A7, GPR183, C3AR1, STEAP1, SLC16A3, CSF3R, TIMP1, CR1, KRT16, SNX10, COTL1, CD53, HCK, SLC39A14, SLC7A11, KLK13, MT1G, CYBB, UPP1, PDPN, CXCR2, KIAA0226L, CSF2RB, TNC, CD14, MT1F, TNFRSF1B, S100A2, THEMIS2, PTPRC, NRG1, MNDA, ADAMTS5, TYMP, ICAM1, CTSL, CYTIP, IGFBP4, HCLS1, CEMIP, PLSCR1, HPSE, MT1E, MT2A, SLAMF8, RRM2, BASP1, CD47, RAC2, PLAU, ITGB2, HS3ST1, VCAN, CDH3, CCR2, CLEC4A, CTSS, TTC39A, TGM2, ITGA4, SLC20A1, DMXL2, S100A8, GCA, LMNB1, PILRA, TNFRSF6B, MPZL2, KRT6A, KRT6B, KRT6C, AREG, ARNTL2
Down-regulated genes	HLF, ID4, ZBTB16, TSPAN8, SGCG, LRRC17, OGN, OMD, BTC

Abbreviations: DEGs, differentially expressed genes.