Analysis of Potential Genes and Pathways Involved in the Pathogenesis of Acne by Bioinformatics

Table 2

KEGG pathway enrichment analysis of genes of Module 1~4 in PPI network.

Term	Description	Count	p-Value	Genes
Module 1
hsa04062	Chemokine signaling pathway	8	2.85E-09	CXCL1, CXCR4, CCR1, CCR2, CXCL2, CXCL8, CCL19, CXCR2
hsa04060	Cytokine-cytokine receptor interaction	8	1.84E-08	CXCL1, CXCR4, CCR1, CCR2, CXCL2, CXCL8, CCL19, CXCR2
hsa05150	Staphylococcus aureus infection	4	7.22E-05	C3AR1, C5AR1, FPR1, FPR2
hsa04080	Neuroactive ligand-receptor interaction	4	0.008378	C3AR1, C5AR1, FPR1, FPR2
hsa05134	Legionellosis	3	0.003179	CXCL1, CXCL2, CXCL8
hsa04621	NOD-like receptor signaling pathway	3	0.003416	CXCL1, CXCL2, CXCL8
hsa05132	Salmonella infection	3	0.007372	CXCL1, CXCL2, CXCL8
Module 2
hsa04610	Complement and coagulation cascades	2	0.058715	PLAU, PLAUR
Module 3
hsa04666	Fc gamma R-mediated phagocytosis	5	1.03E-07	LYN, FCGR1A, HCK, FCGR2A, PIK3R2
hsa04380	Osteoclast differentiation	4	6.56E-05	FCGR1A, FCGR2A, FCGR3A, PIK3R2
hsa05150	Staphylococcus aureus infection	3	5.96E-04	FCGR1A, FCGR2A, FCGR3A
hsa05140	Leishmaniasis	3	0.00103	FCGR1A, FCGR2A, FCGR3A
hsa04611	Platelet activation	3	0.003414	LYN, FCGR2A, PIK3R2
hsa05322	Systemic lupus erythematosus	3	0.003624	FCGR1A, FCGR2A, FCGR3A
hsa04145	Phagosome	3	0.004524	FCGR1A, FCGR2A, FCGR3A
hsa05152	Tuberculosis	3	0.006255	FCGR1A, FCGR2A, FCGR3A
hsa04062	Chemokine signaling pathway	3	0.006891	LYN, HCK, PIK3R2
hsa04664	Fc epsilon RI signaling pathway	2	0.048472	LYN, PIK3R2
hsa04662	B cell receptor signaling pathway	2	0.049171	LYN, PIK3R2
Module 4
hsa04512	ECM-receptor interaction	2	0.049648	TNC, SPP1

Notes: Count, the number of DEGs.
Abbreviations: DEGs, differentially expressed genes; KEGG, Kyoto Encyclopedia of Genes and Genomes; PPI, protein–protein interaction.